Who Collects the Data for Children Diabetes Family Registry

doi: 10.2337/dc12-0445. Epub 2012 Oct 1.

Extended family history of blazon 1 diabetes and phenotype and genotype of newly diagnosed children

Affiliations

• PMID: 23033245
• PMCID: PMC3554291
• DOI: 10.2337/dc12-0445

Free PMC article

Extended family history of type ane diabetes and phenotype and genotype of newly diagnosed children

Anna Parkkola  et al. Diabetes Care. 2013 Feb .

Gratis PMC article

Abstract

Objective: To make up one's mind the frequency of newly diagnosed diabetic children with commencement- and second-degree relatives affected by type 1 diabetes and to narrate the effects of this positive family history on clinical markers, signs of β-jail cell autoimmunity, and HLA genotype in the alphabetize example.

Research blueprint and methods: Children (n = 1,488) with type 1 diabetes diagnosed nether fifteen years of age were included in a cross-exclusive study from the Finnish Pediatric Diabetes Annals. Information on family history of diabetes and metabolic decompensation at diagnosis were collected using a questionnaire. Antibodies to β-cell autoantigens (islet cell antibodies, insulin autoantibodies, GAD antibodies, and antibodies to the islet antigen 2 molecule) and HLA genotypes were analyzed.

Results: A total of 12.2% of the subjects had a first-degree relative with type 1 diabetes (begetter half dozen.2%, mother 3.2%, and sibling 4.viii%) and 11.9% had an affected second-caste relative. Children without affected relatives had lower pH (P < 0.001), higher plasma glucose (P < 0.001) and β-hydroxybutyrate concentrations (P < 0.001), a higher charge per unit of impaired consciousness (P = 0.02), and greater weight loss (P < 0.001). There were no differences in signs of β-cell autoimmunity. The familial cases carried the HLA DR4-DQ8 haplotype more than oft than sporadic cases (74.0 vs. 67.0%, P = 0.02).

Conclusions: When the extended family history of type 1 diabetes is considered, the proportion of desultory diabetes cases may exist reduced to <fourscore%. A positive family unit history for type i diabetes associates with a less astringent metabolic decompensation at diagnosis, even when but second-degree relatives are afflicted. Autoantibody profiles are similar in familial and sporadic type ane diabetes, suggesting similar pathogenetic mechanisms.

Figures

Figure 1

Grouping of the index instance subjects according to who in the extended family was affected by type 1 diabetes. The dashed lines refer to the instance subjects with afflicted relatives from more than one category of relatives. These example subjects are too included in the full number of each category of relatives.

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Source: https://pubmed.ncbi.nlm.nih.gov/23033245/

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